Junior Group Leader Position, Interdisciplinary Institute of Neurosciences (NeuroStra), Strasbourg, France
About the role
The Interdisciplinary Institute of Neurosciences, NeuroStra, is an Institute of Research and Training in Neurosciences funded by the University of Strasbourg, CNRS and INSERM, and starting in January 2021. Gathering 10 laboratories (about 400 members including researchers/professors, administrative/technical staff and students), NeuroStra's ambition is to structure the research and training programs of the Strasbourg Neuroscience teams around their internationally recognized scientific strengths: pain, time processing in the nervous system, and neurogenetic and neurodegenerative diseases.
NeuroStra aims to recruit an outstanding junior scientist to develop a project in line with one of the above priority axes, which levels of investigation can range from molecular to integrated ones, including clinical approaches in humans.
The selected group leader will benefit from a starting package, and she/he will be supported to apply for complementary fundings and for tenured positions at the CNRS, INSERM or University of Strasbourg. The selected group leader will have access to state-of-the-art facilities in molecular and cell biology, in vitro and in vivo electrophysiology, cell and brain imaging, neuroanatomy, electron microscopy, and behavioral and physiological analyses. Appropriate laboratory and office space will be provided.
Applicants should be dynamic and early-career neuroscientists, with the potential to develop an innovative and independent research program, in interaction and collaboration with researchers from NeuroStra. Candidates must meet criteria to compete for national and international research funding and for French institutional research and/or teaching positions (CNRS, INSERM, University). Applicants should have excellent training background and publication track record and:
- preferentially be within the first 10 years following PhD defense;
- already have first name postdoctoral publication (in press or published);
Researchers holding a permanent position in France are welcome to apply.
How to apply
Applications in a single pdf file should include:
- a complete CV, including the list of publications;
- two letters of recommendation;
- descriptions of previous research achievements (1-2 pages);
- a planned research project within the research domains of NeuroStra (2-3 pages);
- 3 original articles (pdf) that the applicant considers her/his main scientific contributions to the field.
All applications will undergo a pre-selection procedure by the NeuroStra Steering Committee. Pre-selected applicants will be evaluated by an independent jury.
PhD student position, BBSRC funded Food DTP network, University of Reading and University of Surrey, UK
Closing date: 8 February 2021
PhD project title: Development of a novel platform for targeting animal parasites
Enquiries: Email Dr. Nandini Vasudevan at email@example.com
Applications: Visit the Food DTP website for more information: research.reading.ac.uk/foodbiosystems/apply-for-a-foodbiosystems-phd/for-phd-students-2/
- Dr. Nandini Vasudevan School of Biological Sciences University of Reading
- Dr. Martha Betson, University of Surrey
- Dr. Eva Kevei, University of Reading
- Professor Liam McGuffin, University of Reading
About the role
We are seeking a highly motivated individual to carry out PhD research on the development of new anthelminthics to increase the quality of animal welfare n the UK, combining molecular biological, parasitological and bioinformatics techniques.
Infections by intestinal parasites is a global problem that decreases animal health and food production. For example, in the UK, the cost of “wormer” or anthelminthic treatments and the loss of animal productivity for the sheep industry costs £84 million/year. In addition, resistance to most classes of anthelmintics is a growing problem. Therefore, sustainable control of these parasites would involve discovering new classes of anthelmintics. However, identification of drug targets and validation of these drug targets is difficult in parasites because they are difficult to culture due to their need for a host and their complex life cycles.
This project will develop an alternative worm model where we can identify novel classes of drug targets using a mix of data-mining and phenotypic screening of potential candidate proteins. The project will utilize two models: the simple nematode, Caenorhabditis elegans as a “stand-in” for parasitic worms to identify and “pre-screen” nuclear hormone receptor drug targets and a parasitic worm model to test these proteins in related cattle and sheep parasites for their ability to stop proliferation. We will attempt to validate a new class of putative drug candidates - namely the nuclear hormone receptors, which are a large class of proteins in C.elegans responsible for reproduction and metabolic regulation. In human, related nuclear hormone receptors are valuable drug targets for diseases such as cancer and metabolic disorders, suggesting that this conserved group of proteins may be good targets for modeling anti-proliferative drugs. Apart from validation of selected nuclear hormone receptors, this project will also give us insight into the functions of these proteins in the worm, where these are largely unknown.
This project represents a uniquely diverse training opportunity as the successful applicant will experience and learn various complimentary research techniques including a blend of in-silico analyses and biological experimentation, will use multiple model systems and be exposed to different research environments by joining on this project led by four research groups (Drs Kevei, Vasudevan, Betson and McGuffin) at two locations (University of Reading and University of Surrey). Students will use genetic, molecular, cell biology, bioinformatics and behavioural techniques in their study. The student will be part of a vibrant endocrine, bioinformatics, veterinary network and food science group at the University of Reading and University of Surrey, with an opportunity to get training in teaching pedagogy. Apart from benefiting from a highly collaborative scheme, the student will also have an opportunity to network with potential overseas collaborators.